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KMID : 1140120070120030200
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Cancer Prevention Research
2007 Volume.12 No. 3 p.200 ~ p.203
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Inhibitory Effects of Berberine on Proliferation of Mouse Lymphoma Cells
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Kim Eun-Young
Cha Bong-Gyu
Kim Kwang-Hyuk
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Abstract
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Berberine, an alkaloid initially isolated from Chinese herbal medicine, has antibiotic activities against a variety of organisms including bacteria, viruses, fungi, protozoans, and chlamydia. Furthermore, berberine has shown a number of beneficial effects, including anti-tumor, anti-inflammation, and vasodilatory effects. In this work we have investigated the effects of berberine on cytotoxic activity against cancer cells and life span of tumor-bearing mice. The direct cytotoxicity of berberine or berberine-combined chemotherapeutic agents for mouse lymphoma cells Yac-1 was observed. In addition, the effect of life span extention was counted on Sarcoma 180 mice injected with berberine-combinated mitomycin C. The effect of growth inhibition for cancer cells, Yac-1 was shown in the cytotoxicity test of berberine or berberine-combinated chemotherapeutic agents. The effect of life span extention was observed at Sarcoma 180 mice injected with berberine-combinated mitomysin C. These findings suggest that berberine shows tumor cell growth inhibition and life span extension in Sarcoma 180 mice exposed with berberine- combinated chemotherapeutic agents. These results show the probability of its usefulness for cancer therapy if more research results were accumulated. (Cancer Prev Res 12, 200-203, 2007)
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KEYWORD
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Berberine, Yac-1, Cytotoxicity, Sarcoma 180
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